Sadly, Blogger (the software on this site) decided to eat all my carefully saved links. And what with my terrible MS memory, I can only remember two of them!
Not to be daunted, I'm going to tell you about those two. I'm really sorry though. Hopefully I'll remember some of the others, and can add them to other roundups in the future.
I've often spoken before about vitamin D and MS. It's a very important area of research at the moment. Now a group of British and Canadian researchers have discovered a rare gene that seems to be linked to MS. The gene is called CYP27B1: a mutation in it affects a key enzyme, leading people with the variant to have lower levels of vitamin D.
They identified the mutation in CYP27B1 as being of interest, from looking at 43 people who came from families with 4 or more individuals affected by MS. Then they looked at over 3,000 unaffected parents of someone with MS. 35 of them carried one copy of the mutated version of CYP27B1 along with a copy of the normal version. In all 35 of these cases, the person with MS inherited the mutated version.
The likelihood of the gene's transmission being unconnected with MS are billions to one, the researchers claim. The very strong implication is that in these particular MS cases, low levels of vitamin D are directly connected to the disease.
It's always been thought that MS begins by attacking myelin in the inner layers of the brain, the white matter. Now American researchers have found that in fact the disease seems to move from the outer, cortical layers of the brain.
The next step for their research is to study these cortical lesions to identify new molecular targets for treatment, and to develop imaging techniques so that these lesions can be shown clearly.
And, well, that's it for December's roundup. Apologies again for the lack of content!
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